Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.5
Supplement Facts
Serving Size: 1 Nugget
Amount Per Serving
%DV
Vitamin B12 (as methylcobalamin)
1000 mcg
41,667%

Top Medical Research Studies

9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.

Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
We explored the intriguing case of a 56-year-old man diagnosed with Biermer's disease, also known as pernicious anemia, an autoimmune condition that leads to a lack of intrinsic factor and, consequently, vitamin B12 malabsorption. This patient presented with unusual symptoms: not just digestive concerns like melena, but also notable neurological effects such as memory issues and gait disturbances.

During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.

The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
We investigated the potential of vitamin B12 as a treatment for rheumatoid arthritis, particularly focusing on its ability to target an enzyme called peptidylarginine deiminase isoform 4 (PADI-4). PADI-4 plays a crucial role in a process called citrullination, which is often disrupted in autoimmune conditions like rheumatoid arthritis.

Our findings revealed that vitamin B12 effectively inhibits PADI-4, showing a preference for this enzyme over another similar one, PADI-2. This inhibition corresponds to a decrease in overall cellular citrullination, including the citrullination of histone H3, which is also mediated by PADI-4.

Additionally, we observed that hydroxocobalamin, a special form of vitamin B12, significantly reduced the severity of collagen type II antibody-induced arthritis in mice. It also lowered the expression of key inflammatory factors and cytokines associated with rheumatoid arthritis, such as IL-17A, TNFα, and IL-6.

These promising results suggest that vitamin B12 might be an effective therapeutic avenue for managing rheumatoid arthritis, warranting further investigation in future studies.

Most Useful Reviews

9
Fast delivery
1 people found this helpful
I was impressed with the super fast delivery time, receiving my order within nine days. The packaging was perfect in a sturdy cardboard box. The product container is excellent as well— a glass bottle with an aluminium screw cap. The sublingual tablets are robust and dissolve easily. The quality is high, and after finishing the bottle, my lab test results for vitamin B12 levels were excellent.
7.5
Maintained health
130 people found this helpful
I purchase these vitamins to maintain a healthy nervous system and am truly impressed with the effect. I take them twice a year and find them easy to store in a pillbox and swallow. I have noticed their effectiveness. If you find this review useful, please like it.
8
Notable improvement
51 people found this helpful
Yes, if my comment helps you, I noticed an improvement after experiencing all the symptoms of vitamin B12 deficiency. I opted for this type, taking one pill every two days under my tongue. It melts and tastes sweet. After two months and 21 days, I did a vitamin B12 test. I would recommend ordering it a second time, but by taking it every three days, my body won't become accustomed to it. I do feel tired if I stop suddenly.

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
  • All Researches
9.5
Vitamin B12 supplementation benefits autoimmune patients
We explored the impact of vitamin B12 on patients with autoimmune disorders, particularly those experiencing symptoms often attributed to their underlying conditions. The study presented three cases of individuals with neuropathic pain, depression, fatigue, and muscle weakness, who had their symptoms initially misattributed to rheumatic diseases.

Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.

Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.

Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
9
Case of combined autoimmune disorders
We examined a fascinating case of a 54-year-old man experiencing the rare overlap of Guillain-Barré Syndrome (GBS) and autoimmune gastritis. After a thorough medical evaluation, which included MRI and biopsy, he was diagnosed with both GBS and a vitamin B12 deficiency linked to atrophic gastritis.

Treatment with intravenous immunoglobulin and methylcobalamin (vitamin B12) led to substantial improvement in his symptoms. This case highlights the importance of recognizing potential nutrient deficiencies, especially those impacting autoimmune disorders like GBS and autoimmune gastritis.
We explored the intriguing case of a 56-year-old man diagnosed with Biermer's disease, also known as pernicious anemia, an autoimmune condition that leads to a lack of intrinsic factor and, consequently, vitamin B12 malabsorption. This patient presented with unusual symptoms: not just digestive concerns like melena, but also notable neurological effects such as memory issues and gait disturbances.

During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.

The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
8
We examined the levels of vitamin B and creatine kinase (CK-NAC) in 50 patients with Guillain-Barré Syndrome (GBS). Through clinical assessments, we compared the patients' functional abilities and found that a deficiency in vitamin B was linked to greater disease severity and respiratory complications.

However, while vitamin B levels seemed to offer insight into GBS prognosis, elevated CK-NAC levels did not show a significant correlation with disease severity. This points towards the importance of monitoring vitamin B as a potential prognostic tool in managing GBS.

User Reviews

USERS' SCORE
Moderately Good
Based on 16 Reviews
7.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Fast delivery
1 people found this helpful
I was impressed with the super fast delivery time, receiving my order within nine days. The packaging was perfect in a sturdy cardboard box. The product container is excellent as well— a glass bottle with an aluminium screw cap. The sublingual tablets are robust and dissolve easily. The quality is high, and after finishing the bottle, my lab test results for vitamin B12 levels were excellent.
7.5
Maintained health
130 people found this helpful
I purchase these vitamins to maintain a healthy nervous system and am truly impressed with the effect. I take them twice a year and find them easy to store in a pillbox and swallow. I have noticed their effectiveness. If you find this review useful, please like it.
8
Notable improvement
51 people found this helpful
Yes, if my comment helps you, I noticed an improvement after experiencing all the symptoms of vitamin B12 deficiency. I opted for this type, taking one pill every two days under my tongue. It melts and tastes sweet. After two months and 21 days, I did a vitamin B12 test. I would recommend ordering it a second time, but by taking it every three days, my body won't become accustomed to it. I do feel tired if I stop suddenly.
9
Doctor's recommendation
14 people found this helpful
I am very pleased with the effect of this vitamin, as my doctor prescribed it alongside chelated iron and folic acid. The results have been excellent, and I'm ordering again.
7.5
Overall improvement
2 people found this helpful
This vegan and gluten-free vitamin B12 is pricier, but I feel secure about the quality. Since starting it, my autoimmune disorder symptoms have improved, and I will provide further feedback if there are additional changes.

Frequently Asked Questions

7.5
Excellent quality
9 people found this helpful
This product is a perfect fit for my daughter and me as vegetarians. Faced with a lack of vitamin B12, we chose this specific one due to its excellent quality. The small tablet has a pleasant taste and dissolves quickly under the tongue. I felt the benefits within about 10-12 days and will continue to order. Regular consumption is essential, not just for vegans and vegetarians. I wish you all good health!
7.5
Increased appetite
1 people found this helpful
B12 Methylcobalamin arrived within nine days with exactly 60 capsules. After 2-3 days of taking it, I felt a surge of energy and an increased appetite. As a new vegetarian, this dietary supplement is perfect for me. Many thanks!
7.5
Stable blood pressure
1 people found this helpful
The doctor informed me that my body struggles to absorb vitamin B12 and folic acid. This supplement is recommended in a split-form. After taking it for six months, my blood pressure no longer drops to critical levels as it had for 15 years. The dosage is convenient, small, odourless, and tasteless, so I buy a larger jar to avoid monthly orders.
7.5
Cognitive improvement
3 people found this helpful
Great! This is the first time I’ve taken B12. I had cognitive disorders like poor memory and trouble concentrating. I believe this supplement has helped resolve those issues.
7.5
Joint comfort
2 people found this helpful
I experienced discomfort in my finger joints and ordered this vitamin. Remarkably, the symptoms improved the next day. The tablets are small and sweet, making them pleasant to take sublingually.
7.5
Positive results
2 people found this helpful
This vitamin is excellent! I frequently purchase it and need to order more whenever I run low. After taking it with meals, my bodily functions have noticeably improved. It’s definitely worth buying.
9
Doctor's recommendation
14 people found this helpful
I am very pleased with the effect of this vitamin, as my doctor prescribed it alongside chelated iron and folic acid. The results have been excellent, and I'm ordering again.
7.5
Overall improvement
2 people found this helpful
This vegan and gluten-free vitamin B12 is pricier, but I feel secure about the quality. Since starting it, my autoimmune disorder symptoms have improved, and I will provide further feedback if there are additional changes.
8
Notable improvement
51 people found this helpful
Yes, if my comment helps you, I noticed an improvement after experiencing all the symptoms of vitamin B12 deficiency. I opted for this type, taking one pill every two days under my tongue. It melts and tastes sweet. After two months and 21 days, I did a vitamin B12 test. I would recommend ordering it a second time, but by taking it every three days, my body won't become accustomed to it. I do feel tired if I stop suddenly.
8
We examined the levels of vitamin B and creatine kinase (CK-NAC) in 50 patients with Guillain-Barré Syndrome (GBS). Through clinical assessments, we compared the patients' functional abilities and found that a deficiency in vitamin B was linked to greater disease severity and respiratory complications.

However, while vitamin B levels seemed to offer insight into GBS prognosis, elevated CK-NAC levels did not show a significant correlation with disease severity. This points towards the importance of monitoring vitamin B as a potential prognostic tool in managing GBS.
We explored a fascinating case of a 40-year-old woman suffering from long-standing, unclear symptoms, initially misdiagnosed with various conditions. After years of monitoring, her critically low vitamin B12 levels were finally recognized, revealing pernicious anemia as the root cause.

Thanks to treatment with B12 injections, we observed significant improvement in her neurological symptoms. This case illustrates the need for thorough evaluations in patients with non-specific symptoms, as addressing vitamin B12 deficiency can lead to meaningful improvements—even when classic signs are absent.
Our exploration focused on how vitamin B12 affects autoimmune disorders, particularly in patients with neurological symptoms like tremors and ataxia. We discovered that some patients have autoantibodies that hinder the body's ability to absorb B12 effectively.

Despite normal levels in the blood, these individuals often had low B12 in their cerebrospinal fluid. Encouragingly, high-dose B12 supplementation alongside immunosuppressive treatments led to improvements in symptoms and increased B12 levels in the cerebrospinal fluid. However, not all patients showed clear B12 deficiency signs from regular blood tests.
9
Case of combined autoimmune disorders
We examined a fascinating case of a 54-year-old man experiencing the rare overlap of Guillain-Barré Syndrome (GBS) and autoimmune gastritis. After a thorough medical evaluation, which included MRI and biopsy, he was diagnosed with both GBS and a vitamin B12 deficiency linked to atrophic gastritis.

Treatment with intravenous immunoglobulin and methylcobalamin (vitamin B12) led to substantial improvement in his symptoms. This case highlights the importance of recognizing potential nutrient deficiencies, especially those impacting autoimmune disorders like GBS and autoimmune gastritis.
8
Vitamin B12 important for anemia
We discovered that vitamin B12 treatment plays a vital role in managing autoimmune conditions like pernicious anemia. In a case involving a 47-year-old woman, she was initially diagnosed with Evans syndrome, which is related to autoimmune hemolytic anemia and thrombocytopenia. After further investigation, she was found to have systemic lupus erythematosus, alongside Hashimoto's thyroiditis.

The treatment plan for our patient included not only immunosuppressive therapies but also vitamin B12 injections, essential for addressing her pernicious anemia. While this case highlighted the importance of B12 in her overall management strategy, it did not provide specific information about its isolated effect on the autoimmune disorder itself.

Importantly, vitamin B12 supplementation is crucial for individuals with certain types of anemia, particularly when the body can't absorb it effectively. However, the details surrounding its impact on autoimmune diseases need further exploration to fully understand its role.

Overall, this report emphasizes that while vitamin B12 is vital for certain conditions, its specific benefits for broader autoimmune disorders remain to be thoroughly evaluated.
9.5
Vitamin B12 supplementation benefits autoimmune patients
We explored the impact of vitamin B12 on patients with autoimmune disorders, particularly those experiencing symptoms often attributed to their underlying conditions. The study presented three cases of individuals with neuropathic pain, depression, fatigue, and muscle weakness, who had their symptoms initially misattributed to rheumatic diseases.

Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.

Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.

References

  1. Jatav VS, Sardana V, Bhushan B, Maheshwari D, Garg S, et al. Correlation of Serum Vitamin B and Muscle Enzyme (CK-NAC) Level with Severity of Guillain-Barre Syndrome and Its Prediction in Respiratory Failure. J Assoc Physicians India. 2025;73:48. 10.59556/japi.73.0892
  2. Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. 10.1186/s13256-025-05149-7
  3. Ma XY, Hao Y, Xie YH, Cao Q, Sun DF, et al. Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case-Control Study in China. J Gastroenterol Hepatol. 2025. 10.1111/jgh.16912
  4. Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. 10.1186/s13256-025-05095-4
  5. Xiang H, Cai M. Coexistence of Guillain-Barré Syndrome and Subacute Combined Degeneration of the Spinal Cord Due to Autoimmune Gastritis: A Case Report and Literature Review. Cureus. 2024;16:e63084. 10.7759/cureus.63084
  6. Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, et al. Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Sci Transl Med. 2024;16:eadl3758. 10.1126/scitranslmed.adl3758
  7. Subtil J, Carvalho R, Rebelo AF, Subtil P. Autoimmune Polyglandular Syndrome Type 3: A Case Report. Cureus. 2024;16:e76152. 10.7759/cureus.76152
  8. Mansour M, Shamasnah A, Alsaadi D, Abu Saif S, Krama A. Evans syndrome as a presentation in systemic lupus erythematous, coexisting with Hashimoto's thyroiditis and pernicious anemia: a case report. J Med Case Rep. 2024;18:643. 10.1186/s13256-024-05002-3
  9. Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. 10.1007/s10067-024-07285-9
  10. Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. 10.1186/s12887-024-05262-4
  11. Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. 10.7759/cureus.58601
  12. Fernandez I, Touzot F. Looking for ALPS: The value of a combined assessment of biochemical markers. Pediatr Allergy Immunol. 2024;35:e14135. 10.1111/pai.14135
  13. Yamada H, Toko M, Nakamori M, Ueno H, Aoki S, et al. Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging. J Neurovirol. 2024;30:197. 10.1007/s13365-024-01203-0
  14. Yang CW, Hsu HY, Lee YZ, Lee SJ. Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice. Biochem Biophys Res Commun. 2024;704:149668. 10.1016/j.bbrc.2024.149668
  15. Dułak NA, Rytlewska M, Jaskólska M, Chmielewski M. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review. Rheumatol Int. 2024;44:737. 10.1007/s00296-024-05539-y
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